Study of Clinical Profile of Patients with Malarial Fever admitted in a Tertiary Care Centre

Authors

  • Gaurav Uday Ghurye Department of General Medicine, Government Medical College, Sindhudurg, Maharashtra, India
  • Nirmala Umesh Sawant Department of General Medicine, Government Medical College, Sindhudurg, Maharashtra, India
  • Vijaykumar Bhagwan Barge Department of General Medicine, Government Medical College, Sindhudurg, Maharashtra, India

Keywords:

Clinical Profile, Laboratory Profile, Malarial Fever, Species Identification

Abstract

Background: Malaria remains a leading cause of human morbidity and mortality due to inability of the insecticide and
chemotherapeutic agents to eliminate the vector and the agent of the disease. The present study is aimed to study the clinical profile, laboratory profile, species identification and line of treatment of the patients as per the species.


Material & Methods: Present study was conducted on 100 confirmed cases of Malaria admitted in Medicine department of Sanjeevan super-specialty hospital, Satara, Maharashtra. All patients were interviewed followed by clinical examination and relevant investigations. Data was entered in MS Excel and statistical analysis was done using EPI-5.


Results: There was male preponderance in my study and incidence was more (84%) in middle age 16-50 years. 100% cases
showed fever as the major symptom followed by nausea (36%), vomiting (36%), headache (22%). Anaemia is common (56%)
followed by thrombocytopaenia (30%). Spleen was palpable in 50% patients. Hyperbilirubinemia was 28% in my study
predominantly of conjugated variety. 72% cases were P. falciparum, 22 % were p. vivax and 6 % were mixed. In the diagnosis, QBC was found to be more sensitive 98% than PBS 78%. for uncomplicated vivax malaria Tab chloroquine showed 60% sensitivity, tab artemether + lumefantrine showed 75% sensitivity, those who were not responding were added with quinine, doxycycline. In falciparum inj. artesunate76 % was more sensitive than quinine 69%. Artemether showed 57% response in falciparum in my study.


Conclusion: Incidence of malaria was more in males than females due to their outdoor stay, travelling and more expose part of the body. Splenomegaly is the most common elicitable sign. Anaemia, thrombocytopaenia are found in falciparum malaria. Multidrug therapy like artemisinin combination therapy has more response in complicated and non-responding cases.

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Published

2023-12-19

How to Cite

Ghurye, G. U., Sawant, N. U., & Barge, V. B. (2023). Study of Clinical Profile of Patients with Malarial Fever admitted in a Tertiary Care Centre. GAIMS Journal of Medical Sciences, 4(1 (Jan-Jun), 120–126. Retrieved from https://gjms.gaims.ac.in/index.php/gjms/article/view/182