Study of Serum Uric Acid and Adenosine Deaminase as Markers of Oxidative Stress in Patients of Type 2 Diabetes Mellitus

Authors

  • Sahema Shaikh Department of Biochemistry, Narendra Modi Medical College, Ahmedabad
  • Bharatkumar Bhoi Department of Biochemistry, Smt. NHL Municipal Medical College, Ahmedabad
  • Mittal Panchal Department of Biochemistry, Swaminarayan Institute of Medical Science and Research, Kalol, Gujarat
  • Amitkumar Maheshwari Department of Biochemistry, Gujarat Adani Institute of Medical Science and GK General Hospital, Bhuj, Kachchh, Gujarat

Abstract

Background: Diabetes Mellitus (DM) is a common metabolic disease due to absolute or relative insulin deficiency. Oxidative stress plays a major role in pathophysiology of type 2 DM and its prevalence is increased due to lifestyle and obesity. In past years different studies has been done to identify various oxidative stress markers. Aim of this study is to evaluate levels of serum Uric Acid (UA), Adenosine Deaminase (ADA), Fasting Plasma Glucose (FPG) and HbA1c in patients of Type 2 Diabetes Mellitus and healthy subject and also to find out role of UA and ADA as a marker of oxidative stress in type 2 DM.

 

Material and methods: We measured the serum level of Uric Acid, ADA, HbA1c and FPG in 100 patients with type 2 diabetes and 50 healthy controls. Subjects included in study group were divided on the basis of duration of diabetes mellitus. Group 1 included subjects with type 2 DM < 1 year and Group 2 included subjects with type 2 DM > 5 year.

 

Results: The difference in FPG, ADA and HbA1c were highly significant (p<0.05) in type 2 diabetic patients (< 1 year) in comparison to control group while the difference in uric acid is not significant in diabetes patients with < 1 year duration and healthy subjects. The difference in FPG, ADA, Uric Acid and HbA1c were highly significant (p<0.05) in type 2 diabetic patients (> 5-year duration) in comparison to control group. While comparing two diabetes groups difference in FPG, ADA, Uric Acid and HbA1c were also highly significant (p<0.05).

 

Conclusion: Uric acid as a predictor of oxidative stress become significant as the duration of diabetes increases while ADA is statistically significant even during early onset of diabetes mellitus.

Downloads

Published

2024-04-24

How to Cite

Shaikh, S., Bhoi, B., Panchal, M., & Maheshwari, A. (2024). Study of Serum Uric Acid and Adenosine Deaminase as Markers of Oxidative Stress in Patients of Type 2 Diabetes Mellitus. GAIMS Journal of Medical Sciences, 4(2 (Jul-Dec), 27–34. Retrieved from https://gjms.gaims.ac.in/index.php/gjms/article/view/217